Calcium Fructoborate (Ca[(C6H10O6)2B]2·4H2O) is an organic complex of calcium (approx. 4.7%), fructose (approx. 84.2%), and boron (max. 2.9%), naturally found in fresh fruits, vegetables, nuts, herbs, wine, and beer. It is considered one of the most bioavailable sources of calcium and boron, making it safer and easier to assimilate than boric acid, borax, or sodium borate. Calcium fructoborate is the only form of boron used in food that is considered safe, stable, non-toxic, and highly biologically active. While calcium’s importance for the human body is well known, the same cannot be said of boron. Organic Boron is an essential nutritional element for human health, but this fact is less known due to earlier misconceptions that boron was non-essential for humans and animals, relevant only for plant development. However, recent studies have shown the vital role of boron in human health, revealing more functions of boron and its derivative compounds.
The World Health Organization recommends an intake of 1-13 mg/day of boron, with a minimum of 3 mg/day (≈ 130.5 mg calcium fructoborate) to ensure optimal nutritional benefits. A deficiency in this mineral may be associated with osteoarticular problems like osteoporosis. Since some boron compounds can be somewhat toxic, Calcium fructoborate is considered the safest source for this element. Studies have demonstrated that Calcium fructoborate is used efficiently in the body at both the cellular and extracellular levels, as it is absorbed in an intact and stable form from the gastrointestinal tract. In conclusion, calcium fructoborate is a natural, safe, and highly bioavailable source of boron and calcium, two essential minerals for the proper functioning of the human body.
The Importance of Calcium Fructoborate
Numerous scientific studies, both domestically and internationally, have verified and confirmed the importance of organic boron, particularly Calcium fructoborate, for overall health, especially the osteoarticular, cardiovascular, and immune systems. A lack of boron in the body is usually associated with:
- Low levels of calcium, magnesium, and phosphorus, due to inefficient absorption of these minerals;
- Low levels of 25-hydroxycholecalciferol (vitamin D3), serum ceruloplasmin (an enzyme relevant to copper metabolism), and erythrocyte superoxide dismutase (SOD) (an enzyme with strong antioxidant action);
- Increased levels of plasma calcium, serum creatinine, and blood urea;
- Bone fragility and increased risk of osteoporosis;
- Reduced mental agility in postmenopausal women and men over 45.
Particularly important for individuals with limited exposure to natural light or those with nutrient-poor diets, supplementation with high-quality organic boron can counteract the harmful effects of dietary vitamin D3 deficiency, making it more efficiently used by the body. This, in turn, supports the metabolism of calcium, magnesium, potassium, and phosphorus, contributing to bone and joint health. The benefits of Calcium fructoborate supplementation are even more significant when adopted from childhood, as organic boron plays a crucial role in growth and bone mass formation.
This bioactive compound is also involved in maintaining the stability and proper functioning of cell membranes. By interacting with biological substances containing cis-hydroxyl functional groups (e.g., glycolipids or phosphoinositides), boron ensures cell membrane stability and influences transmembrane signal transmission. Additionally, boron regulates hormone receptor sensitivity, helping to balance hormones, particularly in menopausal women, by exhibiting estrogenic properties. Scientific studies have shown that this complex reduces the excretion of calcium and magnesium in urine, while also regulating 17β-estradiol and testosterone levels, especially in postmenopausal women. These studies also highlight the importance of organic boron in brain function, with boron deficiency associated with increased copper accumulation in the brain. Boron has been found to improve cognitive performance, including dexterity, attention, and short-term memory.
Animal studies have also demonstrated the immunostimulatory properties of organic boron, showing that supplementation in cattle increases their resistance to BHV1-induced disease. In pigs stimulated with lipopolysaccharide (LPS), boron was shown to affect cytokine release in cell culture supernatants. Consequently, boron enhances the humoral immune response while reducing the inflammatory response. Moreover, through its anti-inflammatory action (by decreasing biomarkers such as hs-CRP and TNF-α), organic boron reduces the incidence and prevalence of osteoarthritis and serves as an effective analgesic, especially when combined with glucosamine, chondroitin, hyaluronic acid, or salicylic acid derivatives (e.g., aspirin, willow bark extract).
Calcium fructoborate also positively affects lipid metabolism, lowering blood cholesterol and triglyceride levels when they exceed normal limits. This is due to its action in enhancing the activity of essential fatty acids such as omega-3 and increasing cellular energy output, which also speeds up wound healing. A diet enriched with Calcium fructoborate can reduce total cholesterol values, offering benefits for patients with dyslipidemia, metabolic disorders, and cardiovascular disease. The compound has also been shown to positively influence uric acid metabolism, reducing the accumulation of this metabolic waste, particularly benefiting individuals suffering from gout.
Last but not least, Calcium fructoborate has notable antioxidant effects, limiting oxidative stress and protecting proteins against the peroxidation process by increasing the values of antioxidant enzymes like superoxide dismutase (SOD), catalase, glutathione peroxidase, and ceruloplasmin. This helps to prevent the oxidation of “bad” cholesterol (LDL), slowing the progression of atherosclerosis. Importantly, organic boron also has anti-tumor and anti-carcinogenic effects, offering protection against cancers such as breast, lung, cervical, and prostate cancer through its antioxidant and radioprotective mechanisms.
Conclusion
In conclusion, Calcium fructoborate is perhaps the best source of boron, as it is stable, non-toxic, and highly bioavailable. Together with maltodextrin, it serves as an excellent adjuvant against the harmful effects of ionizing radiation and contributes significantly to bone health by preventing and reversing bone resorption and reducing the risk of osteoporosis. It also regulates hormones in menopausal women and helps the body efficiently use essential fatty acids, protecting cells and tissues against free radicals. Calcium fructoborate supports the cardiovascular system, strengthens the immune system, limits inflammatory processes, improves cognitive performance, and promotes the proper functioning of the prostate.
Calcium fructoborate is used in many food supplements in the US and is becoming more popular in Europe. Hypericum Impex was the first company to introduce this ingredient into supplements in Romania, using a patented formula.
Organic Boron is recommended for those seeking protection from ionizing radiation, improved bone density, better prostate health, and enhanced cardiovascular and immune system function.
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