CardioBoron

Resveratrol is a well-known polyphenol with significant antioxidant and cardioprotective properties, which contribute to some of the scientific explanations behind the ‘French paradox’. It naturally occurs in various fruits, including red grapes, blueberries, blackberries, and cranberries, as well as in their derivatives (e.g., red wine). Resveratrol exhibits a higher antioxidant capacity than vitamins E, C, and even beta-carotene, making it effective in supporting the body against oxidative stress, cardiovascular disease, and cancer. Additionally, it has a pronounced anti-aging effect.

In summary, products based on Resveratrol can improve microcirculation, thin the blood, facilitate oxygenation of the heart, increase exercise endurance, normalize cholesterol and blood sugar levels, and help tone the myocardium and arteries. Resveratrol also aids in slowing down degenerative processes in the central nervous system and exhibits anti-inflammatory actions.

This powerful compound is present in its natural and bioavailable form in the extract of Asian knotweed (Polygonum cuspidatum), a plant known for its high concentration of phenols, particularly in its rhizomes and roots. The extract boasts a purity of 98% and contains trans-resveratrol.

Calcium fructoborate (Ca[(C₆H₁₀O₆)₂B]₂-4H₂O) is an organic complex of calcium, fructose, and boron, found naturally in fresh fruits, vegetables, nuts, and herbs. It is regarded as one of the most bioavailable sources of calcium and boron and is safer and easier to assimilate than boronic acid, boronate, or boronic compounds. Calcium fructoborate is the only dietary form of boron considered safe, stable, non-toxic, and highly biologically active.

While most people are aware of the importance of calcium for the proper functioning of the human body, boron is often overlooked. Organic boron is an essential nutritional element for human health; however, this fact is not widely recognized. Historically, boron was considered a non-essential element for humans and animals, primarily relevant to plant development. Recent studies, however, have highlighted the significant importance of this microelement, revealing more of its functions and benefits.

The World Health Organization recommends a daily intake of 1-13 mg of boron, with a minimum of 3 mg/day(approximately 130.5 mg of calcium fructoborate) to ensure optimal nutritional benefits. A deficiency in this mineral may be associated with osteoarticular problems such as osteoporosis. Given that some boron compounds can exhibit toxicity, Calcium fructoborate is considered the safest source of this element. Scientific studies have demonstrated that in this form, boron is utilized efficiently in the human body at both the cellular and extracellular levels, as Calcium fructoborate is absorbed intact and in a stable form from the gastrointestinal tract.

In conclusion, Calcium fructoborate serves as a natural, safe, and highly bioavailable source of calcium and boron—two minerals essential for the proper functioning of the human body.

Maltodextrin is a polysaccharide obtained through the partial hydrolysis of starch. Hypericum Laboratories exclusively uses maltodextrin derived from maize, ensuring that there is no risk of causing adverse reactions in individuals with gluten sensitivity or coeliac disease.

Maltodextrin is commonly utilized as a food additive in various sweets and sweetened beverages. In dietary supplements, it typically serves not as an active ingredient but rather as a carrier excipient, particularly in spray-dried preparations. In the case of CardioBoron Capsules, maltodextrin plays a crucial role in enhancing the activity and bioavailability of Calcium fructoborate.

This synergistic effect between Calcium fructoborate and maltodextrin has been validated by the renowned researcher I.R. Scorei, whose studies affirm the benefits of including this excipient in Hypericum’s Boron Organic range of products.

Today, this highly effective combination represents a unique offering in the dietary supplements market!

Importance of Calcium Fructoborate

Numerous scientific studies, both domestically and internationally, have verified and confirmed the importance of organic boron, particularly Calcium fructoborate, for overall health, especially concerning the cardiovascular, osteoarticular, and immune systems. A deficiency of boron in the body is typically associated with:

• Low levels of calcium, magnesium, and phosphorus, resulting from inefficient absorption of these minerals.
• Reduced levels of 25-hydroxycholecalciferol (vitamin D3), serum ceruloplasmin (an enzyme relevant to copper metabolism), and erythrocyte superoxide dismutase (SOD) (an enzyme with strong antioxidant properties).
• Increased levels of plasma calcium, serum creatinine, and blood urea.
• Bone fragility and a heightened risk of osteoporosis.
• Reduced mental agility in postmenopausal women and men over 45.

A pilot clinical study conducted at the University of Craiova Cardiology Centre, led by Dr. Constantin Militaru, focused on the combination of Calcium fructoborate and Resveratrol. The study found that these two compounds exhibit synergistic action, positively impacting the clinical and biological status of patients with angina pectoris and other cardiovascular diseases. In this context, Calcium fructoborate not only supports but also protects Resveratrol. It acts as a stabilizer, combating the degradation of Resveratrol in the digestive tract.

The study demonstrated that the positive synergy between Calcium fructoborate and Resveratrol enhances their biological efficacy as antioxidant and anti-inflammatory agents. In summary, the complementary and synergistic qualities of these compounds provide optimal protection for the cardiovascular system.

Calcium fructoborate also positively impacts lipid metabolism, lowering blood cholesterol and triglyceride levels beyond normal limits. This is attributed to its ability to boost the activity of essential fatty acids, such as omega-3, while increasing cellular energy output, which also accelerates wound healing. A diet enriched with Calcium fructoborate can lead to a reduction in total cholesterol levels, beneficially influencing the condition of patients with dyslipidemia, metabolic disorders, and cardiovascular diseases.

In protecting cardiovascular health, the cholesterol-lowering effect of organic boron is complemented by its antioxidant action. It neutralizes free radicals and enhances the activity of antioxidant enzymes such as superoxide dismutase (SOD), catalase, glutathione peroxidase, ceruloplasmin, and vitamin C. This action prevents the oxidation of lipoproteins, which in turn reduces the formation of LDLox, a contributor to inflammatory processes and atheromatous plaque formation, potentially halting the progression of atherosclerosis. Additionally, beneficial effects on uric acid metabolism have been observed with Calcium fructoborate.

This bioactive compound plays a role in maintaining the stability and proper functioning of cell membranes. By interacting with biological substances that contain cis-hydroxyl functional groups (such as glycolipids or phosphoinositides), boron contributes to cell membrane stability and influences transmembrane signal transmission. Through its regulation of hormone receptor sensitivity, boron aids in balancing hormones in menopausal women, exhibiting estrogenic properties. Scientific studies have indicated that this complex reduces the excretion of calcium and magnesium in urine while regulating 17β-estradiol and testosterone levels, particularly in postmenopausal women.

Moreover, these studies underscore the importance of organic boron concerning brain function, as boron deficiency is linked to increased copper accumulation in the brain. Boron has been shown to enhance cognitive performance, including dexterity, attention, and short-term memory.

Supplementation with high-quality organic boron is particularly important for individuals who lack sufficient exposure to natural light or have nutrient-poor diets. This supplementation can counteract the harmful effects of dietary deficiencies in vitamin D3, enhancing its utilization in the body. Consequently, this supports the metabolism of calcium, magnesium, potassium, and phosphorus, with positive implications for heart, immune, bone, and joint health. The benefits of Calcium fructoborate supplementation are even more pronounced when initiated from childhood, as organic boron plays a crucial role in growth and bone mass formation.

Animal studies have also demonstrated the immunostimulatory properties of organic boron, with cattle supplementation leading to increased resistance to BHV1-induced disease. In pigs stimulated with lipopolysaccharide (LPS), boron was found to influence cytokine release in cell culture supernatants. Thus, boron appears to enhance the humoral immune response while diminishing the inflammatory response. Additionally, due to its anti-inflammatory action (e.g., lowering the values of biomarkers hs-CRP and TNF-α), organic boron reduces the incidence and prevalence of osteoarthritis and serves as an effective analgesic for such conditions, especially when combined with hyaluronic acid and salicylic acid (e.g., aspirin, willow bark extract). The antioxidant and immunomodulatory actions of organic boron are also linked to its antitumor and anticancer effects. Recent studies have shown that organic boron provides protective benefits against various cancers, including breast, lung, cervical, and prostate cancer.

In conclusion, through the synergistic action of Resveratrol, Calcium fructoborate, and maltodextrin, this supplement contributes to normal coronary and arterial blood flow while enhancing the heart’s oxygenation capacity. Maltodextrin amplifies the effectiveness of Calcium fructoborate, which acts as a stabilizer for Resveratrol, preventing its degradation in the digestive tract. The positive synergy between Calcium fructoborate and Resveratrol has been shown to enhance their biological efficacy as antioxidants and anti-inflammatory agents. Together, these two active compounds help strengthen the walls of blood vessels, facilitate relaxation and dilation of the arteries, and normalize blood pressure. They also restore the balance between the two main types of lipoproteins (HDL and LDL), protect against their oxidation, and limit triglyceride levels in the blood. Last but not least, this product can help reduce the need for nitroglycerin.