Artro-Flex HA

Hyaluronic acid (also known as hyaluronan) is a large glycosaminoglycan synthesized in the plasma membrane, found in significant quantities in epithelial, connective, and neural tissues. It plays an essential role in maintaining joint flexibilityand mobility by stimulating the synthesis and increasing the viscosity of synovial fluid, which acts as a natural lubricant for cartilage. As a major constituent of extracellular matrices, hyaluronic acid aids in repairing injuries or scars in epithelial tissues by stimulating collagen production and providing antioxidant and moisturizing benefits for the skin.

The most commonly used form of hyaluronic acid is injectable, often used in advanced cases of osteoarthritis to reduce pain and improve mobility. In many cases, hyaluronic acid injections are the last alternative before surgery. These injections are also used in facial treatments to tone and smooth expression lines. However, despite their effectiveness, injections can be both painful and expensive. This has led to increasing interest in the prophylactic and therapeutic effects of oral hyaluronic acid supplements. For instance, a study by Japanese researchers showed that oral supplementation with 200 mg of hyaluronic acid per day for one year, combined with quadriceps toning exercises, improved osteoarthritis symptoms in subjects, with notable effects after just 2 to 4 months. Even participants aged 70 years reported significant improvements.

In cosmetics, hyaluronic acid is prized for its role in maintaining skin suppleness, elasticity, and firmness. This is due to its ability to stimulate collagen synthesis, promote keratinocyte proliferation, and retain moisture—being a hydrophilic molecule capable of holding up to 1,000 times its weight in water. This results in smoother skin, wrinkle reduction, and enhanced skin recovery from ultraviolet radiation damage (e.g., after sun exposure). Unfortunately, hyaluronic acid has a rapid turnover rate in the body, especially in the epidermis, necessitating daily replenishment. Its levels decrease with age, smoking, substance abuse, or after the age of 40, making both external and internal supplementation essential to maintain youthful skin characteristics.

In this formula, we use medium molecular weight hyaluronic acid, biotechnologically derived from plant sources through bacterial fermentation. This type has been shown to be superior for internal use and effective in facilitating the transport of active compounds like coenzyme Q10, synergizing for notable anti-aging effects—including wrinkle reduction, improved skin elasticity, and enhanced softness and hydration. Beyond the skin, studies indicate beneficial effects on skeletal muscles, further enhancing its value. In this product, hyaluronic acid complements the anti-inflammatory and antioxidant properties of organic boron, making it essential to choose products with holistic and synergistic formulas.

Calcium Fructoborate (Ca[(C6H10O6)2B]2-4H2O) is an organic complex of calcium, fructose, and boron, naturally found in fresh fruits, vegetables, nuts, and herbs. It is considered one of the most bioavailable sources of calcium and boron, being safer and easier to assimilate than other boron compounds. While calcium’s importance is well-known, boron’s essential role in human health has only recently been recognized, following discoveries that highlight its significant impact on bone health, joint function, and immune system support.

The World Health Organization recommends a daily boron intake of 1-13 mg, with a minimum of 3 mg/day (≈ 130.5 mg calcium fructoborate) for optimal benefits. Boron deficiency is often associated with osteoporosis and joint problems, and calcium fructoborate is the safest source of this mineral. Research has shown that calcium fructoborate is absorbed efficiently in a stable form, making it highly effective in promoting bone health, supporting hormonal balance, and enhancing cognitive function.

Boron deficiency is linked to low levels of calcium, magnesium, and phosphorus, and higher risks of bone fragility, reduced mental agility (especially in postmenopausal women and men over 45), and even diminished brain function. Supplementation with organic boron supports the metabolism of essential minerals and promotes better utilization of vitamin D3, which in turn enhances bone and joint health, especially when boron intake begins in childhood.

Calcium fructoborate plays a role in maintaining cell membrane stability by reacting with biological substances such as glycolipids and phosphoinositides, influencing hormonal regulation and helping to balance estrogen levels in postmenopausal women. Studies also highlight its beneficial impact on lipid metabolism, helping reduce cholesterol and triglyceride levels, while also aiding in the management of uric acid levels, particularly benefiting those with gout.

Recent clinical studies have demonstrated the synergistic action of calcium fructoborate with resveratrol, particularly for cardiovascular health. This combination enhances the antioxidant and anti-inflammatory effects of both compounds, offering significant protection to the cardiovascular system.

Calcium fructoborate also synergizes well with hyaluronic acid, as both compounds reduce oxidative stress and protect joints from free radical damage. Boron further protects against the peroxidation of lipoproteins, limiting the formation of atheromatous plaques and supporting the body’s natural defenses against cancer.

Animal studies show that boron enhances immune response, reducing the inflammatory markers hs-CRP and TNF-αand acting as a potent analgesic for conditions such as osteoarthritis, especially when combined with hyaluronic acidand salicylic acid.

In short, calcium fructoborate is an excellent adjunct in maintaining osteojoint health, protecting cartilage from oxidative and inflammatory damage, and reducing the risk of osteoporosis by stimulating bone formation. It also aids in hormonal balance, especially during menopause, and enhances the body’s use of essential fatty acids, while promoting cardiovascular health and immune function.

In conclusion, the synergy of hyaluronic acid and calcium fructoborate in Artro-Flex HA helps protect and regenerate the joint and bone systems, mitigating the negative effects of inflammation, autoimmune reactions, and oxidative stress. Hyaluronic acid also helps maintain adequate synovial fluid levels, ensuring joint lubrication and mobility even during periods of mechanical overload from intense physical activities or excess weight.